GNE 140
(R)-GNE-140 ；GNE140
CAS: 2003234-63-5
Molecular Formula: C25H23ClN2O3S2
GNE 140 - Names and Identifiers
GNE 140 - Physico-chemical Properties
| Molecular Formula | C25H23ClN2O3S2 |
| Molar Mass | 499.04 |
| Density | 1.46±0.1 g/cm3(Predicted) |
| Boling Point | 695.4±55.0 °C(Predicted) |
| Solubility | DMSO : 14.43 mg/mL (28.92 mM);H2O : < 0.1 mg/mL (insoluble) |
| pKa | 4.50±1.00(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| In vitro study | (R)-GNE-140 inhibits proliferation in 37 of 347 cancer cell lines tested at a potency cut off of 5 μM. (R)-GNE-140 shows inhibitory effect on two chondrosarcoma (bone) cancer cell lines that harbor IDH1 mutations, with IC 50 of 0.8 μM. |
| In vivo study | (R)-GNE-140 (5 mg/kg) has high bioavailability in mice. At higher oral doses, ranging from 50 to 200 mg/kg, (R)-GNE-140 displays greater exposure. |
GNE 140 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.004 ml | 10.019 ml | 20.038 ml |
| 5 mM | 0.401 ml | 2.004 ml | 4.008 ml |
| 10 mM | 0.2 ml | 1.002 ml | 2.004 ml |
| 5 mM | 0.04 ml | 0.2 ml | 0.401 ml |
Last Update：2024-01-02 23:10:35
GNE 140 - Introduction
About (R)-GNE-140; The use of GNE140 is also unknown. The use of chemical substances is usually determined according to their properties and chemical reactions.
Similarly, regarding the preparation method of (R)-GNE-140 ;GNE140, due to lack of relevant information, I cannot provide a detailed preparation method.
As for safety information, due to the lack of specific data about (R)-GNE-140 ;GNE140, it is impossible to provide accurate information about its safety. In order to ensure safety, it is important to observe laboratory safety rules and instructions for the use of chemicals, and to observe appropriate handling and disposal measures in case of toxicity or danger.
Last Update：2024-04-10 22:29:15
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Spot supply
Product Name: (R)-GNE-140 ；GNE140 Visit Supplier Webpage Request for quotationCAS: 2003234-63-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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